Article
FLT3 inhibition as a targeted therapy for acute myeloid leukemia.
Current opinion in oncology - 1 Nov 2009
Sanz Miguel, Burnett Alan, Lo-Coco Francesco, Löwenberg Bob
Abstract excerpt
PURPOSE OF REVIEW: The management of acute myeloid leukemia (AML) presents significant challenges, and there remains a need for new therapies with greater efficacy and better tolerability than existing treatments. An improved understanding of the genetic and molecular changes underlying AML can h...
Topics
- Acute Disease
- Animals
- Carbazoles
- Drug Evaluation, Preclinical
- Furans
- Humans
- Leukemia, Myeloid
- Molecular Structure
- Mutation
- Staurosporine
- fms-Like Tyrosine Kinase 3