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Design of a pharmacokinetic-pharmacodynamic model for administration of low dose peripheral norepinephrine during general anaesthesia

2024-05-22

Abstract excerpt

<h4>Introduction: </h4> Poor intra-operative blood pressure is a risk factor for kidney, heart, and cognitive post-operative complications. Literature suggests that use of low-dose peripheral norepinephrine (NOR) reduces organ dysfunction, yet its administration remains unstandardized. In this work we develop a pharmacokinetic/pharmacodynamics (PK/PD) model of NOR effect on mean arterial pressure (mAP). <h4>Method...

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Literature Corpus work
428b49bf-1050-5afb-aced-3d3df4f2152f
DOI
10.22541/au.171639167.70573550/v1
Open publication

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Design of a pharmacokinetic-pharmacodynamic model for administration of low dose peripheral norepinephrine during general anaesthesiaDOI 10.22541/au.171639167.70573550/v1
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