Article
Enhancement of Antitumor Immunity via the Inhibition of Ferroptosis-mediated Endoplasmic Reticulum Rupture Links IDH Mutation with Glioma Prognosis
2025-10-22
Abstract excerpt
<title>Abstract</title> <p> Objective Ferroptosis, an iron-dependent programmed cell death, results in poor glioma prognosis via the suppression of anti-tumor immunity. Given that Ca <sup>2+</sup> stored in the endoplasmic reticulum plays an important role in immune signaling, and the endoplasmic reticulum is a key target of ferroptosis, we tested the hypothesis that IDH mutation enhances anti-tumor immunity v...
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Identifiers and source
- Literature Corpus work
- 401d7109-b6a2-5d0c-8a43-06a23c36e281
- DOI
- 10.21203/rs.3.rs-7915302/v1