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Duration of Antibiotic Prophylaxis, Early-Onset Ventilator-Associated Pneumonia and Selection of Multidrug-Resistant Organisms in Mechanically Ventilated Patients with Traumatic Brain Injury: A Retrospective Cohort Study

2026-08-05

Abstract excerpt

<h4>Background: </h4> /Objectives: Ventilator-associated pneumonia (VAP) is the leading indication for antibiotic therapy in intensive care units (ICUs), and patients with traumatic brain injury (TBI) are at particularly high risk of early-onset VAP (eVAP). Antibiotic prophylaxis reduces eVAP but may exert selective pressure favouring multidrug-resistant (MDR) organisms. We assessed whether prophylactic exposure e...

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Literature Corpus work
3a6ef557-3ce1-5c69-ae42-d327dc42057d
DOI
10.20944/preprints202608.0303.v1
Open publication

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Duration of Antibiotic Prophylaxis, Early-Onset Ventilator-Associated Pneumonia and Selection of Multidrug-Resistant Organisms in Mechanically Ventilated Patients with Traumatic Brain Injury: A Retrospective Cohort StudyDOI 10.20944/preprints202608.0303.v1
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