Article

Let-7b-5p differentially regulates human first trimester trophoblast migration and sFlt-1 through TLR7 and TLR8

2026-08-07

Abstract excerpt

<h4>Introduction</h4> Preeclampsia is characterized by a pro-inflammatory, anti-migratory and anti-angiogenic placental phenotype. Impaired spiral artery remodeling stemming from trophoblast dysfunction is a key pathogenic mechanism. Little is known about the processes that govern trophoblast function normally and in preeclampsia. In preeclampsia, placental Let-7b-5p is reduced. The objectives of this study were...

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Literature Corpus work: 39be9343-f9f5-541e-81a2-4f4ed3d6209c
DOI: 10.64898/2026.08.03.742516

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