Article

Disentangling Brain-Psychopathology Associations: A Systematic Evaluation of Transdiagnostic Latent Factor Models

2025-12-23

Abstract excerpt

Identifying robust brain-psychopathology associations with neuroimaging remains difficult, in part due to substantial heterogeneity within and comorbidity between diagnostic categories. Transdiagnostic latent factor models aim to address this structure by separating shared and unique symptom variance. However, it remains unclear whether latent factor modeling translates into stronger and more interpretable brain-p...

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Literature Corpus work: 384b6009-b758-5286-bf20-f9f4d62af104
DOI: 10.64898/2025.12.21.695029

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