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Beyond Antimicrobial Resistance Phenotypes: Host Immune-Inflammatory Dysregulation, Physiological Severity, and Bloodstream Dissemination as Convergent Determinants of In-Hospital Mortality in ICU Klebsiella pneumoniae Infections: A Prospective Observational Study

2026-05-28

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<title>Abstract</title> <p> <bold>Background:</bold> <italic>Klebsiella pneumoniae</italic> is a major pathogen in intensive care units (ICUs), frequently associated with multidrug resistance (MDR). However, clinical outcomes may be influenced more by host-related factors than by antimicrobial resistance (AMR) phenotypes alone. This study evaluated the relative contributions of physiological severity, host imm...

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Literature Corpus work
3253e10e-d7fb-5758-a416-5e5d4cb04eba
DOI
10.21203/rs.3.rs-9630173/v1
Open publication

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Beyond Antimicrobial Resistance Phenotypes: Host Immune-Inflammatory Dysregulation, Physiological Severity, and Bloodstream Dissemination as Convergent Determinants of In-Hospital Mortality in ICU Klebsiella pneumoniae Infections: A Prospective Observational StudyDOI 10.21203/rs.3.rs-9630173/v1
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