Article

Comparative Label-Free Quantitative Proteomics of Hypomineralised Second Primary Molars (HSPM) and Molar–Incisor Hypomineralisation (MIH) reveals divergent enamel protein signatures underpinning distinct pathogenic mechanisms

2026-05-19

Abstract excerpt

<title>Abstract</title> <p>Purpose Despite sharing clinical features and an overlapping mineralisation window, HSPM and MIH differ at the molecular level in their enamel matrix composition, which remains uncharacterised. This study aimed to directly compare the enamel matrix proteomes of HSPM and MIH using label-free quantitative proteomics to identify differentially abundant proteins and elucidate condition-spe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2cb86f2a-0389-5849-a591-7365531bc30a
DOI: 10.21203/rs.3.rs-9587147/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative Label-Free Quantitative Proteomics of Hypomineralised Second Primary Molars (HSPM) and Molar–Incisor Hypomineralisation (MIH) reveals divergent enamel protein signatures underpinning distinct pathogenic mechanismsDOI 10.21203/rs.3.rs-9587147/v1Read

Salivary Proteomic Patterns in Children Affected by Different Severity Degrees of Molar Incisor HypomineralizationSemantic proximity Read

Proteomic pipeline to identify age-related compositional and structural changes of the human dentin extracellular matrixSemantic proximity Read

Archaeological preservation of amelogenesis pathwaysSemantic proximity Read

Identification by whole-exome sequencing of new single-nucleotide polymorphisms associated with molar-incisor hypomineralisation among the Lebanese population.Semantic proximity Read

Proteomic signatures of equine dental tooth tissues in ageing and diseaseSemantic proximity Read

DENTAL ENAMEL FORMATION AND IMPLICATIONS FOR ORAL HEALTH AND DISEASE.Semantic proximity Read

Mass Spectrometry-Based Proteomic Approaches for Salivary Biomarkers in Patients with Fixed Orthodontic Appliances and the Invisalign System: A Non-Randomized Clinical TrialSemantic proximity Read

Analysis of 5000 year-old human teeth using optimized large-scale and targeted proteomics approaches for detection of sex-specific peptidesSemantic proximity Read

Protein-Based Salivary Profiles as Novel Biomarkers for Oral DiseasesSemantic proximity Read

Phenotypes of Enamel Hypomineralization and Molar Incisor Hypomineralization in Permanent Dentition: Identification, Quantification and Proposal for Classification.Semantic proximity Read

The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis.Semantic proximity Read

The molecular basis of hereditary enamel defects in humans.Semantic proximity Read