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Plausible Blockers of Spike RBD in SARS-CoV2 – Molecular Design and Underlying Interaction Dynamics from High-Level Structural Descriptors<b> </b>

2021-03-04

Abstract excerpt

COVID-19 is characterized by an unprecedented abrupt increase in the viral transmission rate (SARS-CoV-2) relative to its pandemic evolutionary ancestor, SARS-CoV (2003). The complex molecular cascade of events related to the viral pathogenicity is triggered by the Spike protein upon interacting with the ACE2 receptor on human lung cells through its receptor binding domain (RBDSpike). One potential therapeutic str...

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Literature Corpus work
2cb04910-c743-5990-be29-35d057983582
DOI
10.20944/preprints202009.0006.v2
Open publication

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