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PARP-inhibitors Improve Progression-Free Survival in Breast Cancer Patients with Previous Platinum Exposure – A Systematic Review and Meta-Analysis

2023-06-26

Abstract excerpt

<title>Abstract</title> <p>Importance: The poly-adenosine diphosphate–ribose polymerase (PARP) enzymes are important for DNA single-strand break repair and PARP inhibitors (PARPi) cause an accumulation of unresolved DNA damage in tumors with <italic>BRCA1/2</italic> mutations, resulting in cell death. However, because platinum salts also ultimately cause double-strand DNA breaks and may have overlapping mechanis...

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Literature Corpus work
2c3da902-68fe-5d5d-801e-91e0c58c584d
DOI
10.21203/rs.3.rs-2869964/v1
Open publication

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PARP-inhibitors Improve Progression-Free Survival in Breast Cancer Patients with Previous Platinum Exposure – A Systematic Review and Meta-AnalysisDOI 10.21203/rs.3.rs-2869964/v1
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