Article

Improving Real-world Antigen Test Sensitivity Estimation through Target Distribution Balancing

2024-10-28

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> Sensitivity is a key measure of lateral-flow antigen test (AT) performance, typically compared against qRT-PCR as the gold standard. For COVID-19, diagnostic sensitivity assesses the ability of ATs to detect SARS-CoV-2 nucleoprotein. However, sensitivity estimates can be strongly skewed by variations of the target concentrations within the clinical sample sets. Independent stud...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2c315daf-8e57-5fe2-adfe-eea42f6ace24
DOI: 10.1101/2024.10.25.24316137

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Improving Real-world Antigen Test Sensitivity Estimation through Target Distribution BalancingDOI 10.1101/2024.10.25.24316137Read

Clinical and experimental factors that affect the reported performance characteristics of rapid testing for SARS-CoV-2Semantic proximity Read

Comparative performance of SARS CoV-2 lateral flow antigen tests demonstrates their utility for high sensitivity detection of infectious virus in clinical specimensSemantic proximity Read

Diagnosing SARS-CoV-2 with Antigen Testing, Transcription-Mediated Amplification and Real-Time PCRSemantic proximity Read

Assessment of twenty-two SARS-CoV-2 rapid antigen tests against SARS-CoV-2: A laboratory evaluation studySemantic proximity Read

Performance of High Throughput SARS-CoV-2 Antigen Testing Compared to Nucleic Acid TestingSemantic proximity Read

The Coviral Portal: Multi-Cohort Viral Loads and Antigen-Test Virtual Trials for COVID-19Semantic proximity Read

The Impact of Repeating COVID-19 Rapid Antigen Tests on on Prevalence Boundary Performance and Missed DiagnosesSemantic proximity Read

Harmonization of Real-World Data for Vaccine-Preventable Infectious Diseases: Integration of SARS-CoV-2 Diagnostic and Serologic Data from Multiple SourcesSemantic proximity Read

Estimating the false positive rate of highly automated SARS-CoV-2 nucleic acid amplification testingSemantic proximity Read

Hybrid Statistical Learning for COVID-19 Testing Operations: A Multitask Modeling of Positivity, Viral Load and Turnaround TimeSemantic proximity Read

Test Agreement Between Roche Cobas 6800 and Cepheid GeneXpert Xpress SARS-CoV-2 Assays at High Cycle Threshold RangesSemantic proximity Read

A data-driven consensus framework for Ct interpretation in real-world multi-assay qPCR diagnosticsSemantic proximity Read