Article

Selective Disruption of Mutant TP63 Alleles Restores Corneal Epithelial proliferation in EEC Syndrome

2026-02-11

Abstract excerpt

Ectrodactyly–Ectodermal Dysplasia–Cleft Lip/Palate (EEC) syndrome is a rare disorder caused by dominant-negative mutations in the TP63 gene, frequently leading to limbal stem cell deficiency (LSCD) and progressive corneal degeneration. Current therapeutic strategies are limited, primarily due to impaired epithelial renewal and poor proliferative capacity of patient-derived cells. We have recently shown that decrea...

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Literature Corpus work: 2966360b-46c1-5e86-b57b-7d0b73dbbbde
DOI: 10.64898/2026.02.09.704349

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