Article

Inflammatory bowel disease risk gene C1ORF106 regulates actin dynamics in intestinal epithelial cells

2025-03-15

Abstract excerpt

<h4>Background and aims</h4> C1ORF106 has previously been associated with inflammatory bowel diseases (IBD) via large-scale genetic studies. Increased intestinal permeability is a hallmark of IBD and is observed in at-risk individuals prior to the appearance of clinical symptoms. C1ORF106 was previously shown to regulate intestinal barrier permeability through the regulation of adherens junction stability and thr...

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Literature Corpus work: 2376d728-d1af-5dda-af33-fd9910d9d935
DOI: 10.1101/2025.03.14.643205

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