Article

Hypogonadism, adipose tissue inflammation, and adipose tissue circadian clock disruption promote metabolic dysfunction in Klinefelter syndrome

2026-02-13

Abstract excerpt

<title>Abstract</title> <p>Sex chromosome aneuploidies like Klinefelter syndrome (KS) represent a naturally occurring genetic model to investigate metabolic function at the intersection of sex chromosomes, hypogonadism and sex hormone replacement therapy. Men with KS have severe metabolic dysfunction and a more than 2.5-fold increased risk of type 2 diabetes. We assessed body composition, insulin sensitivity, and...

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Literature Corpus work: 2023094e-5316-5c1d-a5f3-6c614eb0691b
DOI: 10.21203/rs.3.rs-8850956/v1

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