Article

Long-term antidepressant use and outcomes in adults: A systematic review

2026-08-18

Abstract excerpt

<p>Aims: This is the first study to systematically review the evidence for the outcomes (adverse or beneficial) associated with long-term (>12 months) antidepressant use in adults (18 years or over). Millions of people are taking antidepressants long-term, yet without evidence for the associated outcomes are unable to make an informed choice about whether to continue or attempt stopping. <h4>Methods:</h4> We se...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1f47806e-6dee-5b8a-8ee6-4c970f429631
DOI: 10.31234/osf.io/s4ej8_v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Long-term antidepressant use and outcomes in adults: A systematic reviewDOI 10.31234/osf.io/s4ej8_v1Read

RELEASE (REdressing Long-tErm Antidepressant uSE): Protocol for a 3-arm pragmatic cluster randomised controlled trial effectiveness-implementation hybrid type-1 in general practiceSemantic proximity Read

Global prevalence of antidepressant utilization in the community: A protocol for a systematic reviewSemantic proximity Read

Suicide risk with selective serotonin reuptake inhibitors and new-generation serotonergic-noradrenergic antidepressants in adults: a systematic review and meta-analysis of observational studiesSemantic proximity Read

Understanding antidepressant change patterns in the UK BiobankSemantic proximity Read

Redressing long-term antidepressant use (RELEASE): Pragmatic cluster randomised controlled trial in general practiceSemantic proximity Read

Multimorbidity in Older Adults with Depression Study (MODS) (Behavioural Activation to improve physical and mental functioning among older people with multiple long-term conditions): Protocol for a fully powered randomised controlled trialSemantic proximity Read

Protocol For a Scoping Review of Patient-Preferred Outcomes in Depressive DisordersSemantic proximity Read

SSRI prescription during acute COVID-19 and risk of Long COVID symptoms and conditions among patients with depressionSemantic proximity Read

Do no harm: a paradigm shift in the unchecked use of antidepressants.Semantic proximity Read

Predicting intentions towards long-term antidepressant use in the management of people with depression in primary care: A longitudinal survey studySemantic proximity Read

Low predictive power of clinical features for relapse prediction after antidepressant discontinuation in a naturalistic settingSemantic proximity Read

The impact of the COVID-19 pandemic on Antidepressant Prescribing with a focus on people with learning disability and autism: An interrupted time-series analysis in England using OpenSAFELY-TPPSemantic proximity Read