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An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: protocol

2024-06-17

Abstract excerpt

Valproate is the most effective treatment for idiopathic generalised epilepsy. Currently, its use is restricted in women of childbearing potential owing to high teratogenicity. Recent evidence extended this risk to men’s offspring, prompting recommendations to restrict use in everybody aged <55 years. This study will evaluate mortality and morbidity risks associated with valproate withdrawal by emulating a hypothe...

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Literature Corpus work
1e94d9d7-31bb-5fc0-8262-2f247678ada0
DOI
10.1101/2024.06.16.24308993
Open publication

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