Leveraging Diverse Regulated Cell Death for Prognostic Prediction of Pancreatic Cancer Using Machine Learning and Multi-omics Analysis

Abstract excerpt

<title>Abstract</title> <p>Pancreatic cancer is an aggressive form of cancer with poor prognosis. Recent findings indicate that regulated cell death (RCD) significantly contributes to tumor growth, which could be a potential prognostic indicator for pancreatic cancer. We utilized weighted gene co-expression network analysis to extract 103 genes shared by different subtypes of RCD (apoptosis, ferroptosis, necropto...

Topics

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• Autophagy in Disease and Therapy
• Cell death mechanisms and regulation
• Epigenetics and DNA Methylation
• Ferroptosis and cancer prognosis
• Pancreatic and Hepatic Oncology Research
• PARP inhibition in cancer therapy
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

1bd4b5e5-4051-5fa8-bca7-db8c15a3a9c4

DOI

10.21203/rs.3.rs-3639799/v1