Article

Discovery of a novel fungal Tc toxin complex and a functional myco- serpin via a unique two-by-two comparative genomics pipeline

2025-03-21

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Fungi have been a rich source of pharmaceuticals such as antibiotics, immunosuppressants, and cholesterol-lowering drugs; however, their therapeutic potential remains largely untapped due to difficulties in culturing and elucidating the genetic basis of beneficial traits. Fungi contain 'cryptic' genes that are expressed under certain, and often obscure, growth...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1ba7fd19-5d59-52d0-9d6f-30fc1bd7a9f1
DOI: 10.21203/rs.3.rs-6005389/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery of a novel fungal Tc toxin complex and a functional myco- serpin via a unique two-by-two comparative genomics pipelineDOI 10.21203/rs.3.rs-6005389/v1Read

Strategies for mining fungal natural productsSemantic proximity Read

Comparative genomics of beetle-vectored fungal pathogens reveals a reduction in genome size and independent evolution of pathogenicity of two tree pathogensSemantic proximity Read

Conservation of a gene cluster reveals novel cercosporin biosynthetic mechanisms and extends production to the genus <i>Colletotrichum</i>Semantic proximity Read

Genome-wide exploration of biosynthetic gene clusters and their association to virulence in the entomopathogenic fungus BeauveriaSemantic proximity Read

Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus speciesSemantic proximity Read

Identification of new signalling peptides through a genome-wide survey of 250 fungal secretomesSemantic proximity Read

Fungi.guru: Comparative genomic and transcriptomic resource for the fungi kingdomSemantic proximity Read

De novo chromosome-level genome assembly of two mycoparasitic hypocreaceous fungiSemantic proximity Read

Evolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural ProductsSemantic proximity Read

From Morphology to Multi-Omics: A New Age of Fusarium ResearchSemantic proximity Read

Bioinformatic Analysis of Secondary Metabolite Biosynthetic Potential in Pathogenic FusariumSemantic proximity Read

Discovery of Novel Targets for Important Human and Plant Fungal Pathogens via Automated Computational Pipeline HitListSemantic proximity Read