Article

NGS-defined measurable residual disease (MRD) after initial chemotherapy as a prognostic biomarker for acute myeloid leukemia

2022-12-29

Abstract excerpt

<title>Abstract</title> <p>Treated AML patients often have measurable residual disease (MRD) due to persisting low-level clones. This study assessed whether residual post-treatment somatic mutations, detected by NGS, were significantly prognostic for subsequent clinical outcomes. AML patients (n = 128) underwent both pre-and post-treatment testing with the same 42-gene MRD-validated NGS assay. After induction, 59...

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Literature Corpus work: 1b7b8238-3f96-5b88-988b-b1b327680047
DOI: 10.21203/rs.3.rs-2386724/v1

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