Article

Predictive single cell foundation model for gene regulation and aging with privacy-preserving tabular learning

2026-07-09

Abstract excerpt

<title>Abstract</title> <p>Pre-trained foundation models (FMs) have begun transforming single-cell genomics, but scaling them raises privacy concerns. Moreover, unlike text data, single-cell data is unordered and exhibits a unique tabular structure that current single-cell FMs overlook. We introduce Tabula, a privacy-preserving FM designed with federated learning (FL) that explicitly models the tabular structure...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a0c06ae-747c-574a-aa1a-99eec686a6e0
DOI: 10.21203/rs.3.rs-10274933/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Predictive single cell foundation model for gene regulation and aging with privacy-preserving tabular learningDOI 10.21203/rs.3.rs-10274933/v1Read

Toward a privacy-preserving predictive foundation model of single-cell transcriptomics with federated learning and tabular modelingSemantic proximity Read

FedscGen: privacy-aware federated batch effect correction of single-cell RNA sequencing dataSemantic proximity Read

Tabular Foundation Models Are Competitive Cellular Perturbation Predictors Across Biological ScalesSemantic proximity Read

Stack: In-Context Learning of Single-Cell BiologySemantic proximity Read

A Pan-Cancer Multi-Omic SuperLearner for Regulated Cell Death Survival TopologiesSemantic proximity Read

Virtual-cell verification enables self-auditing AI discovery for immune rejuvenationSemantic proximity Read

DeepSeq: High-Throughput Single-Cell RNA Sequencing Data Labeling via Web Search-Augmented Agentic Generative AI Foundation ModelsSemantic proximity Read

PantheonOS: An Evolvable Multi-Agent Framework for Automatic Genomics DiscoverySemantic proximity Read

TwinCell: Large Causal Cell Model for Reliable and Interpretable Therapeutic Target PrioritisationSemantic proximity Read

Benchmarking a foundational cell model for post-perturbation RNAseq predictionSemantic proximity Read

PersonaAI: An Interactive Agentic-AI Framework for Autonomous Hypothesis Generation and Validation in AgingSemantic proximity Read

Integrating Artificial Intelligence with Genomic and Biomarker Data for the Advancement of Personalized Therapeutics in a Human-Centric FrameworkSemantic proximity Read