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Development and Validation of Minimal Disease Activity, Disease Flare, and Minimal Clinically Important Difference for Children with Chronic Nonbacterial Osteomyelitis Using a Consensus and Data-Driven Approach

2025-12-04

Abstract excerpt

<h4>Objectives</h4> To create definitions for minimal disease activity (MDA), flare, and minimal clinically important difference (MCID) for chronic nonbacterial osteomyelitis (CNO). It is necessary to establish these criteria prior to starting clinical effectiveness trials for therapies in CNO. <h4>Methods</h4> Three separate cohorts samples from an international observational CNO registry were presented to a pa...

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Literature Corpus work
195d3d2a-602b-5ec3-a937-13d7b734b454
DOI
10.64898/2025.12.04.25340995
Open publication

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