Article

Misexpression of inactive genes in whole blood is associated with nearby rare structural variants

2023-11-19

Abstract excerpt

Gene misexpression is the aberrant transcription of a gene in a context where it is usually inactive. Despite its known pathological consequences in specific rare diseases, we have a limited understanding of its wider prevalence and mechanisms in humans. To address this, we analyzed gene misexpression in 4,568 whole blood bulk RNA sequencing samples from INTERVAL study blood donors. We found that while individual...

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Literature Corpus work: 1933f4cf-054e-5a10-9841-9b3c48b1a7f5
DOI: 10.1101/2023.11.17.567537

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