Article

Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to <i>Shigella flexneri</i>

2022-10-03

Abstract excerpt

<h4>ABSTRACT</h4> Shigella flexneri is a human adapted pathovar of Escherichia coli that can invade the intestinal epithelium, causing inflammation and bacillary dysentery. Although an important human pathogen, the host response to S. flexneri is poorly understood. Zebrafish larvae, highly innovative for genomics, transcriptomics and genetic tractability, represent a valuable animal model to study human infecti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1838459b-27e0-5bb9-902c-53e7e50cd98f
DOI: 10.1101/2022.10.03.510593

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to <i>Shigella flexneri</i>DOI 10.1101/2022.10.03.510593Read

High-resolution analysis of spatiotemporal virulence gene regulation during food-borne infection with <i>Escherichia coli</i> O157:H7 within a live hostSemantic proximity Read

Colonization of larval zebrafish ( <i>Danio rer</i> io) with adherent-invasive <i>Escherichia coli</i> prevents recovery of the intestinal mucosa from drug-induced colitisSemantic proximity Read

SINGLE CELL RESOLUTION OF THE ADULT ZEBRAFISH INTESTINE UNDER CONVENTIONAL CONDITIONS, AND IN RESPONSE TO AN ACUTE <i>VIBRIO CHOLERAE</i> INFECTIONSemantic proximity Read

Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiaeSemantic proximity Read

The zebrafish as a model to study intestinal inflammationSemantic proximity Read

Similarly Lethal Strains of Extraintestinal Pathogenic Escherichia coli Trigger Markedly Diverse Host Responses in a Zebrafish Model of SepsisSemantic proximity Read

Transcriptome profiling of zebrafish infected with Streptococcus suisSemantic proximity Read

Shiga toxin remodels the intestinal epithelial transcriptional response to Enterohemorrhagic Escherichia coliSemantic proximity Read

Zebrafish larvae as experimental model to expedite the search for new biomarkers and treatments for neonatal sepsisSemantic proximity Read

Host transcriptomic profiling of CD-1 outbred mice with severe clinical outcomes following infection with <i>Orientia tsutsugamushi</i>Semantic proximity Read

Host Immune Response and Acute Disease in a Zebrafish Model of<i>Francisella</i>PathogenesisSemantic proximity Read

Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel diseaseSemantic proximity Read