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Microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in <i>Trappc9</i> KO mice

2023-11-20

Abstract excerpt

Mutations of the human TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9 ( TRAPPC9 ) cause a neurodevelopmental disorder characterised by microcephaly and intellectual disability. Trappc9 constitutes a subunit specific to the intracellular membrane-associated TrappII complex. The TrappII complex interacts with Rab11 and Rab18, the latter being specifically associated with lipid droplets (LDs). Here we used non-inva...

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Literature Corpus work
17666d94-c147-5521-b73b-d5af15fd5eab
DOI
10.1101/2023.11.20.567859
Open publication

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Microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in <i>Trappc9</i> KO miceDOI 10.1101/2023.11.20.567859
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