Article

Development of Sustained Release, Anti-Cytokine Short Interfering RNA (siRNA) Therapy for Equine Osteoarthritis

2016-01-01

Abstract excerpt

Synovitis is a key mediator of osteoarthritis (OA) and in the perpetuation of cartilage degradation, and approximately 60% of lameness in the horse has previously been attributed to OA. Synovial inflammation is characterised by a mononuclear cell infiltration into the synovial membrane, with concurrent increases in catabolic cytokines predominantly produced by synovial macrophages. These cytokines cause changes in...

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Literature Corpus work: 16d75be3-7276-5190-b3f0-ca7edf76f561
DOI: 10.17638/03001722

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