Article

Comprehensive Analysis of the Expression and Prognosis of 12 Cytochrome P450s in Human Hepatocellular Carcinoma from the Perspective of Network Pharmacology

2020-08-19

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Cytochrome P450s (CYPs) are pivotal drug metabolic enzymes and play a crucial part in the development and prognosis of hepatocellular carcinoma (HCC). Among various CYPs, 12 (CYP1A2, 27A1, 2A6, 2A7, 2B6, 2C8, 2C9, 2E1, 2J2, 3A4, 3A5, and 4A11) are recognized as key therapeutic targets for HCC from the perspective of network pharmacology. However, the gene expres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 114f3f0c-6f55-5952-a5fe-41d6acbad227
DOI: 10.21203/rs.3.rs-60063/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comprehensive Analysis of the Expression and Prognosis of 12 Cytochrome P450s in Human Hepatocellular Carcinoma from the Perspective of Network PharmacologyDOI 10.21203/rs.3.rs-60063/v1Read

Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular CarcinomaSemantic proximity Read

Integrated analysis of hepatocellular carcinoma reveals disparate subtype of prognosis significanceSemantic proximity Read

Identification of hub genes and potential drugs in hepatocellular carcinoma through integrated bioinformatics analysisSemantic proximity Read

Comprehensive Network Analysis of the Molecular Mechanisms Associated with Sorafenib Resistance in Hepatocellular CarcinomaSemantic proximity Read

Prognostic implications of alcohol dehydrogenases in hepatocellular carcinomaSemantic proximity Read

Bioinformatics analysis revealed hub genes and pathways involved in sorafenib resistance in hepatocellular carcinomaSemantic proximity Read

Cytochrome P450 family members are associated with fast-growing hepatocellular carcinoma and patient survival: An integrated analysis of gene expression profilesSemantic proximity Read

SOCS2 is a potential prognostic marker that suppresses the viability of hepatocellular carcinoma cellsSemantic proximity Read

Target prediction and potential application of dihydroartemisin on hepatocarcinomaSemantic proximity Read

Decoding the mechanism of andrographolide to combat hepatocellular carcinoma: a network pharmacology integrated molecular docking and dynamics approachSemantic proximity Read

Expression and Prognostic Roles of PRDXs Gene Family in Hepatocellular CarcinomaSemantic proximity Read

Screening of HRas, RRas and FOS as Potential Pharmacodynamic Candidates for the Treatment of Hepatocellular CarcinomaSemantic proximity Read