Back to search

Article

Acne Transcriptomics: Fundamentals in Acne Pathogenesis and Isotretinoin Treatment

2023-10-09

Abstract excerpt

This review provides information on acne transcriptomics allowing deeper insights into acne pathogenesis and isotretinoin´s mode of action. Puberty-induced insulin-like growth factor 1 (IGF-1), insulin and androgen signaling activate the kinase AKT and mechanistic target of rapamycin complex 1 (mTORC1). Western diet (hyperglycemic carbohydrates, milk/dairy products) as well co-stimulate AKT/mTORC1 signaling. AKT-m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
10b3bcf6-8929-5270-bada-07813b379f57
DOI
10.20944/preprints202310.0472.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Acne Transcriptomics: Fundamentals in Acne Pathogenesis and Isotretinoin TreatmentDOI 10.20944/preprints202310.0472.v1
FoxO1 – the key for the pathogenesis and therapy of acne?Semantic proximity
Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgarisSemantic proximity
Role of insulin resistance and diet in acneSemantic proximity
The Genetics of AcneSemantic proximity
Effect of oral isotretinoin on the nucleo‐cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgarisSemantic proximity
Homeostasis of the sebaceous gland and mechanisms of acne pathogenesisSemantic proximity
Acne vulgaris: an inflammasomopathy of the sebaceous follicle induced by deviated FoxO1/ <scp>mTORC</scp> 1 signallingSemantic proximity
Sebocyte differentiation as a new target for acne therapy: an in vivo experienceSemantic proximity
Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesisSemantic proximity
Darier disease.Semantic proximity
Genome-wide association meta-regression identifies stem cell lineage orchestration as a key driver of acne riskSemantic proximity
Etiopathogenesis and Emerging Methods for Treatment of VitiligoSemantic proximity
Select a neighboring publication to make it the new centre.