Article

An integrated analysis of amniotic fluid reveals a dynamic prenatal microbial landscape and regulatory axis

2025-07-29

Abstract excerpt

Challenging the sterile womb dogma, our study investigated amniotic fluid (AF) microbial colonization and its potential role in foetal immune development. We analysed microbial presence in 154 AF samples without clinical and analytical suspicion of AF infection using optimised bacterial culture methods and full-length 16S rRNA gene sequencing. Shotgun metagenomic sequencing was also performed on a subset of cultur...

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Literature Corpus work: 0e932c4c-4a49-5938-98bc-bf662b1cee17
DOI: 10.1101/2025.07.29.25331497

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