Article

Similarities and Differences in the Late-Onset GM2 Gangliosidoses: Tay-Sachs and Sandhoff Diseases

2025-08-08

Abstract excerpt

The two predominating subtypes of late-onset GM2 gangliosidosis are late-onset Tay-Sachs (LOTS) and late-onset Sandhoff disease (LOSD). Due to shared deficiencies of ß-hexosamindase A and significant clinical overlap, the two diseases have been considered indistinguishable. However, a growing body of evidence supports the notion of several distinctions between the two diseases. In this study, we highlight these di...

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Literature Corpus work: 0db70ae2-cd08-55ab-a8d2-8fbc86b4a1fa
DOI: 10.1101/2025.08.05.25333048

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