Article

YTHDC2 Promotes the Apoptosis of Colorectal Cancer Cells Through the p38MAPK Signaling Pathway

2020-05-18

Abstract excerpt

<title>Abstract</title> <p>Background The role of the m<sup>6</sup>A-binding protein YTHDC2 in the occurrence and development of colorectal cancer (CRC) is unclear. We aimed to explore the molecular mechanisms underlying this process and clarify the signaling pathway involved. Methods Firstly, the relationship between YTHDC2 and CRC in TCGA database was analyzed to identify relevant signaling pathways and biolo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b843265-b86b-54f8-9dc6-c7a9e0561def
DOI: 10.21203/rs.3.rs-27416/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

YTHDC2 Promotes the Apoptosis of Colorectal Cancer Cells Through the p38MAPK Signaling PathwayDOI 10.21203/rs.3.rs-27416/v1Read

Cuproptosis-related gene ACAD8 inhibits the metastatic ability of colorectal cancer by inducing cuproptosisSemantic proximity Read

Pyrroline-5-Carboxylate Reductase-2 as a Potential Prognostic Biomarker of Colorectal Cancer: A Study Based on Bioinformatics ApproachesSemantic proximity Read

Pan-Cancer Analysis Reveals SH3TC2 as an Oncogene for Colorectal Cancer and Promotes Tumorigenesis via the MAPK PathwaySemantic proximity Read

SH2D2A as a VEGF pathway-related oncogene driving colorectal cancer through mTOR activationSemantic proximity Read

OTOP2, Inversely Modulated by miR-3148, Inhibits CRC Cell Migration, Proliferation and Epithelial–Mesenchymal Transition: Evidence from Bioinformatics Data Mining and Experimental VerificationSemantic proximity Read

YTHDC1 serves as a potential therapeutic target and is linked with the immune microenvironment in Pan cancerSemantic proximity Read

Over-expression of YTHDC2 Contributes to Progression of Prostate Cancer and Predicts Poor Outcome in Patients with Prostate CancerSemantic proximity Read

ABHD6 suppresses colorectal cancer progression via AKT signaling pathwaySemantic proximity Read

Nuclear division cycle 80 promotes malignant progression and predicts clinical outcome in colorectal cancerSemantic proximity Read

Chaperonin Containing TCP-1 subunit 6A (CCT6A) is involved in development of colon cancerSemantic proximity Read

Mechanisms Underlying Cancer Growth and Apoptosis by DEK Overexpression in Colorectal CancerSemantic proximity Read

Long non-coding RNA colon cancer-associated transcript 2: role and function in human cancersSemantic proximity Read