Article

The obesity-linked human lncRNA AATBC regulates adipocyte plasticity by stimulating mitochondrial dynamics and respiration

2021-08-09

Abstract excerpt

Adipocytes are critical regulators of metabolism and energy balance. While white adipocyte dysfunction is a hallmark of obesity-associated disorders, the activation of thermogenic brown and beige adipocytes is linked to improved cardiometabolic health. As adipocytes dynamically adapt to environmental cues by functionally switching between white and thermogenic phenotypes, a molecular understanding of this adipocyt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 07bc5f51-6b8a-51d8-8d3f-559a4a1580d3
DOI: 10.1101/2021.08.09.455681

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The obesity-linked human lncRNA AATBC regulates adipocyte plasticity by stimulating mitochondrial dynamics and respirationDOI 10.1101/2021.08.09.455681Read

Single-cell analysis of white adipose tissue reveals the tumor-promoting adipocyte subtypesSemantic proximity Read

Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMISemantic proximity Read

Shortcuts to a functional adipose tissue: The role of small non-coding RNAs.Semantic proximity Read

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite CellsSemantic proximity Read

Thermogenic genes are blunted whereas brown adipose tissue identity is preserved in human obesitySemantic proximity Read

Multidimensional Single-Nuclei RNA-Seq Reconstruction of Adipose Tissue Reveals Adipocyte Plasticity Underlying Thermogenic ResponseSemantic proximity Read

The long noncoding RNA Blnc1 orchestrates homeostatic adipose tissue remodeling to preserve metabolic healthSemantic proximity Read

Adipocyte mesenchymal transition contributes to mammary tumor progressionSemantic proximity Read

Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cellsSemantic proximity Read

The long noncoding RNA MALAT1 modulates adipose loss in cancer-associated cachexia by suppressing adipogenesis through PPAR-γSemantic proximity Read

De novo reconstruction of human adipose transcriptome reveals conserved lncRNAs as regulators of brown adipogenesisSemantic proximity Read

Single-cell RNA-sequencing reveals a unique landscape of the tumor microenvironment in obesity-associated breast cancerSemantic proximity Read