Article

Cardiac involvement in Fabry disease: Implications of retinal vessel analysis in detecting early microvascular alterations despite ERT

2025-01-15

Abstract excerpt

<h4>Background</h4> Cardiac complications driven by microvascular changes are one of the primary reasons for mortality in patients with Fabry disease (FD). While enzyme replacement therapy (ERT) can effectively clear globotriaosylceramide (Gb3) deposits in the endothelium, it remains controversial whether ERT fully resolves microvascular dysfunction, particularly in advanced cases. <h4>Methods</h4> We conducted a...

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Literature Corpus work: 07a99e57-536a-5952-98f1-3b8979336a58
DOI: 10.1101/2025.01.14.25320513

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