Article

Multi-method computational evaluation of the inhibitors against leucine-rich repeat kinase 2 G2019S mutant for Parkinson's disease

2023-09-08

Abstract excerpt

Leucine-rich repeat kinase 2 G2019S mutant (LRRK2 G2019S) is a potential target for Parkinson's disease therapy. In this work, the computational evaluation of the LRRK2 G2019S inhibitors was conducted via a combined approach which contains a preliminary screening of a large database of compounds via similarity and pharmacophore, a secondary selection via structure-based affinity prediction and molecular docking, a...

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Literature Corpus work: 069ee5ea-ec0a-573d-9c1f-100d0aa5a4b0
DOI: 10.21203/rs.3.rs-3327280/v1

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