Back to search

Article

Identification of a gene signature closely related to immunosuppressive tumor microenvironment predicting prognosis of patients in EGFR mutant lung adenocarcinoma

2020-08-01

Abstract excerpt

<h4>Background: </h4> Lung adenocarcinomas (LUAD) harboring epidermal growth factor receptor (EGFR) mutations generally are unable to benefit from immune checkpoint inhibitors (ICIs), due to an immunosuppressive tumor microenvironment (TME) and a lower tumor mutation burden (TMB). Currently, there has been no gene signature that can comprehensively evaluate the TME and predict the prognosis of EGFR mutant LUAD pat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
04a025b5-4723-53f4-9b8d-ae8a2861ab45
DOI
10.21203/rs.3.rs-46728/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Identification of a gene signature closely related to immunosuppressive tumor microenvironment predicting prognosis of patients in EGFR mutant lung adenocarcinomaDOI 10.21203/rs.3.rs-46728/v1
Identification of an immune-related genes signature in lung adenocarcinoma to predict survival and response to immune checkpoint inhibitorsSemantic proximity
An immune gene signature to predict prognosis and immunotherapeutic response in lung adenocarcinomaSemantic proximity
An Immune Gene Signature for Prediction of Overall Survival and Response to Immune Checkpoint Inhibitors Therapy in Patients with Lung AdenocarcinomaSemantic proximity
Immune Score Closely Associated With Tumor Microenvironment as A Prognostic Factor in Lung AdenocarcinomaSemantic proximity
Microenvironment Analysis of Prognosis and Molecular Signature of Immune-Related Genes in Lung Adenocarcinoma.Semantic proximity
Development and validation of an immune‐related prognostic signature in lung adenocarcinomaSemantic proximity
A risk model developed based on tumor microenvironment predicts overall survival and associates with tumor immunity of patients with lung adenocarcinoma.Semantic proximity
Comprehensive analysis of prognostic immune-related genes in the tumor microenvironment of lung adenocarcinomaSemantic proximity
A Novel Prognostic Signature Revealed the Interaction of Immune Cells in Tumor Microenvironment Based on Single-Cell RNA Sequencing for Lung AdenocarcinomaSemantic proximity
Unraveling the Expression Patterns of Immune Checkpoints Identifies New Subtypes and Emerging Therapeutic Indicators in Lung AdenocarcinomaSemantic proximity
BIRC5 expression correlated with immunosuppressive phenotype and predicted inferior response to immunotherapy in lung adenocarcinomaSemantic proximity
A Prognostic Nomogram Combining Immune-Related Gene Signature and Clinical Factors Predicts Survival in Patients With Lung AdenocarcinomaSemantic proximity
Select a neighboring publication to make it the new centre.