Article

HitSV: Maximizing discovery of structural variants across sequencing technologies

2026-02-20

Abstract excerpt

<title>Abstract</title> <p>Structural variants (SVs) are a major source of genomic diversity, yet their discovery remains challenging due to repetitive genomic contexts, alignment ambiguity, and the trade-off between sequencing cost and read length. Here we introduce HitSV, which substantially improves SV discovery by implementing repetitiveness and signature density aware breakpoint recognition coupled with prec...

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Literature Corpus work: 02a924cb-de09-58d4-8bdc-54be5c4edcfd
DOI: 10.21203/rs.3.rs-8913458/v1

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