Article

Individual-First Brain State Modeling Reconciles Personalized Prediction with Generalizable Mechanistic Interpretation in Precision Psychiatry

2026-04-29

Abstract excerpt

Neuropsychiatric heterogeneity creates a fundamental trade-off between personalized prediction and generalizable mechanistic interpretation. Conventional brain metastate models enforce shared state repertoires, inherently suppressing clinically meaningful individual variation, whereas individualized brain states lack direct correspondence across participants, limiting cross-subject comparison. We present Individua...

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Literature Corpus work: 01f14b7b-dab5-5d3b-9c2e-ddcb5098d054
DOI: 10.64898/2026.04.28.26351834

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