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Modeling patient variants of Cnot1 and Cdc42bpb results in distinct forms of congenital diaphragmatic hernia in mice

2026-02-26

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Congenital diaphragmatic hernia (CDH) is a severe congenital anomaly characterized by impairment of both diaphragm and lung development in utero . CDH presents as a spectrum of forms and severities, with diaphragm defects arising in the dorsal/posterior region typically correlating with more severe pulmonary disease and higher risk of mortality than those appearing in ventral/anterior regions. The genetic etiolog...

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Literature Corpus work: 0027efb7-9d03-5ab6-8620-f19136b85ed9
DOI: 10.64898/2026.02.24.707527

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Modeling patient variants of <i>Cnot1</i> and <i>Cdc42bpb</i> results in distinct forms of congenital diaphragmatic hernia in mice

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