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Article

Ferrochelatase structural mutant (Fechm1Pas) in the house mouse.

Genomics - 1 Jun 1993

Boulechfar S, Lamoril J, Montagutelli X, Guenet J L, Deybach J C, Nordmann Y, Dailey H, Grandchamp B, de Verneuil H

Abstract excerpt

The molecular basis of an inherited defect of ferrochelatase in mouse (Fechm1Pas/Fechm1Pas, described by Tutois et al., 1991, J. Clin. Invest. 88:1730-1736) was investigated. cDNA clones encoding ferrochelatase, isolated by amplification of the mRNA from the liver of a mutant mouse using the polymerase chain reaction, were sequenced by the dideoxynucleotide chain-termination method. All the clones carried a T to...

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PMID: 8325637
DOI: 10.1006/geno.1993.1242

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