Article
Dominant optic atrophy. Refining the clinical diagnostic criteria in light of genetic linkage studies.
Ophthalmology - 1 Jan 1999
Johnston R L, Seller M J, Behnam J T, Burdon M A, Spalton D J
Abstract excerpt
OBJECTIVE: To describe the clinical findings and refine the clinical diagnostic criteria for dominant optic atrophy based on eight British families in which the diagnosis was confirmed by linkage analysis. DESIGN AND PARTICIPANTS: Case series; 92 subjects in 8 pedigrees had both eyes examined. IN...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Chromosomes, Human, Pair 3
- DNA
- Genes, Dominant
- Genetic Linkage
- Genotype
- Haplotypes
- Humans
- Middle Aged
- Optic Atrophies, Hereditary
- Pedigree
- Visual Acuity