Characterization of a Novel Simian Immunodeficiency Virus (SIV) from L’Hoest Monkeys ( Cercopithecus l’hoesti ): Implications for the Origins of SIVmnd and Other Primate Lentiviruses

Abstract excerpt

The human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) appear to have originated by cross-species transmission of simian immunodeficiency virus (SIV) from asymptomatically infected African primates. Few of the SIVs characterized to date efficiently infect human primary lymphocytes. Interesting, two of the three identified to infect such cultures (SIVsm and SIVcpz) have appeared in human populations as...

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