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Article

Mutators and long-term molecular evolution of pathogenic Escherichia coli O157:H7.

Emerging infectious diseases - 1 Jan 2000

Whittam T S, Reid S D, Selander R K

Abstract excerpt

It has been proposed that an increased mutation rate (indicated by the frequency of hypermutable isolates) has facilitated the emergence of Escherichia coli O157:H7. Analysis of the divergence of 12 genes shows no evidence that the pathogen has undergone an unusually high rate of mutation and molecular evolution.

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Identifiers

PMID: 9866737
DOI: 10.3201/eid0404.980411
PMCID: PMC2640239

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