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Article

Mutations that extend the specificity of the endonuclease activity of lambda terminase.

Journal of bacteriology - 1 Jan 1999

Arens J S, Hang Q, Hwang Y, Tuma B, Max S, Feiss M

Abstract excerpt

Terminase, an enzyme encoded by the Nu1 and A genes of bacteriophage lambda, is crucial for packaging concatemeric DNA into virions. cosN, a 22-bp segment, is the site on the virus chromosome where terminase introduces staggered nicks to cut the concatemer to generate unit-length virion chromosomes. Although cosN is rotationally symmetric, mutations in cosN have asymmetric effects. The cosN G2C mutation (a G-to-C...

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Identifiers

PMID: 9864333
DOI: 10.1128/JB.181.1.218-224.1999
PMCID: PMC103552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutations that extend the specificity of the endonuclease activity of lambda terminase.PMID 9864333Read ↗

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Genetic analysis of cosB, the binding site for terminase, the DNA packaging enzyme of bacteriophage lambda.Semantic proximity Read ↗

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