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Article

Variable distribution of TFF2 (Spasmolysin) alleles in Europeans does not indicate predisposition to gastric cancer.

Human heredity - 1 Jan 1999

dos Santos Silva E, Kayademir T, Regateiro F, Machado J C, Savas S, Dobosz T, Blin N, Gött P

Abstract excerpt

Peptides belonging to the trefoil factor family (TFF) protect the gastrointestinal epithelia. Overexpression of TFFs was observed in pathological conditions such as gastritis, ulceration, metaplasia and neoplasia of the gastrointestinal tract. The aims of this work were to investigate the recentl...

Topics

Alleles
Europe
Gene Frequency
Genetic Predisposition to Disease
Growth Substances
Humans
Mucins
Muscle Proteins
Neuropeptides
Peptides
Polymerase Chain Reaction
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stomach Neoplasms

Tandem Repeat Sequences

Trefoil Factor-2

Trefoil Factor-3

Source

Identifiers

PMID: 9858857
DOI: 10.1159/000022839

Genes

TFF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9858857-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Variable distribution of TFF2 (Spasmolysin) alleles in Europeans does not indicate predisposition to gastric cancer.PMID 9858857Read ↗

A novel 25 bp tandem repeat within the human trefoil peptide gene TFF2 in 21q22.3: polymorphism and mammalian evolution.Semantic proximity Read ↗

A PvuII polymorphism detected by a cDNA clone of the gene encoding the human spasmolytic protein protein (SML1 gene), one of three members of the trefoil peptide gene family clustered on chromosome 21q22.3.Semantic proximity Read ↗

TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury.Semantic proximity Read ↗

TFF1 gene single nucleotide polymorphism (rs3761376) and colorectal cancer risk.Semantic proximity Read ↗

Promoter polymorphisms in trefoil factor 2 and trefoil factor 3 genes and susceptibility to gastric cancer and atrophic gastritis among Chinese population.Semantic proximity Read ↗

Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection.Semantic proximity Read ↗

Association study of FUT2 (rs601338) with celiac disease and inflammatory bowel disease in the Finnish population.Semantic proximity Read ↗

The Gene Encoding Human Intestinal Trefoil Factor (TFF3) Is Located on Chromosome 21q22.3 Clustered with Other Members of the Trefoil Peptide FamilySemantic proximity Read ↗

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