Article
Dystrophic phenotype induced in vitro by antibody blockade of muscle alpha-dystroglycan-laminin interaction.
Journal of cell science - 1 Jan 1999
Brown S C, Fassati A, Popplewell L, Page A M, Henry M D, Campbell K P, Dickson G
Abstract excerpt
alpha-dystroglycan is a glycoprotein expressed on the surface of skeletal muscle fibres and other cell types. In muscle, alpha-dystroglycan provides a link between the myofibre cytoskeleton through its indirect binding to dystrophin, and the basal lamina through its binding to laminin-2, a protei...
Topics
- Animals
- Antibodies, Monoclonal
- Cell Differentiation
- Cell Fusion
- Cells, Cultured
- Cytoskeletal Proteins
- Dystroglycans
- Laminin
- Membrane Glycoproteins
- Mice
- Microscopy, Electron
- Muscle, Skeletal
- Muscular Dystrophy, Animal
- Phenotype
- Protein Binding