Article
Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1, P1, and M1 and cytochrome P450 2E1.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 1998
Lin D X, Tang Y M, Peng Q, Lu S X, Ambrosone C B, Kadlubar F F
Abstract excerpt
Genetic polymorphisms in enzymes involved in carcinogen metabolism have been shown to influence susceptibility to cancer. Cytochrome P450 2E1 (CYP2E1) is primarily responsible for the bioactivation of many low molecular weight carcinogens, including certain nitrosamines, whereas glutathione S-tra...
Topics
- Adult
- Aged
- Case-Control Studies
- Cytochrome P-450 CYP2E1
- DNA Primers
- Esophageal Neoplasms
- Female
- Genetic Predisposition to Disease
- Glutathione Transferase
- Humans
- Male
- Middle Aged
- Pilot Projects
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length