Fine-scale mapping of a novel dementia gene, PLOSL, by linkage disequilibrium.

doi:10.1006/geno.1998.5591

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Article

Fine-scale mapping of a novel dementia gene, PLOSL, by linkage disequilibrium.

Genomics - 1 Dec 1998

Pekkarinen P, Kestilä M, Paloneva J, Terwillign J, Varilo T, Järvi O, Hakola P, Peltonen L

Abstract excerpt

Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL; MIM 221770) is a rare hereditary cause of presenile dementia with autosomal recessive inheritance. Its unique feature is the cystic bone lesions that accompany the dementia. About 160 cases have been reported to...

Topics

Adaptor Proteins, Signal Transducing
Alleles
Chromosome Mapping
Chromosomes, Human, Pair 19
Dementia
Demography
Female
Finland
Genetic Linkage
Haplotypes
Humans
Linkage Disequilibrium
Lod Score
Male
Membrane Proteins
Microsatellite Repeats
Molecular Sequence Data
Pedigree

Source

Open in PubMed

Identifiers

PMID: 9828133
DOI: 10.1006/geno.1998.5591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9828133-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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