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Article

Transgenic cattle produced by reverse-transcribed gene transfer in oocytes

24 Nov 1998

Abstract excerpt

A critical requirement for integration of retroviruses, other than HIV and possibly related lentiviruses, is the breakdown of the nuclear envelope during mitosis. Nuclear envelope breakdown occurs during mitotic M-phase, the envelope reforming immediately after cell division, thereby permitting the translocation of the retroviral preintegration complex into the nucleus and enabling integration to proceed. In the...

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PMID: 9826647
DOI: 10.1073/pnas.95.24.14028

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