Article
[Molecular genetics of alterations in the mitochondrial respiratory chain].
Revista de neurologia - 1 Apr 1998
Martín M A, Campos Y, de Bustos F, del Hoyo P, Rubio J C, Arenas J
Abstract excerpt
Mitochondrial biogenesis is the result of the coordinated action of two genomes, nuclear (nDNA) and mitochondrial (mtDNA). Therefore respiratory chain defects are divided into alterations of mtDNA and of nDNA. The former may be due to sporadic isolated deletions and specific duplications and mutations, which are both transmitted maternally. The nDNA disorders are inherited following a mendelian pattern and may...
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