[Molecular genetics of alterations in the mitochondrial respiratory chain].

Article

[Molecular genetics of alterations in the mitochondrial respiratory chain].

Revista de neurologia - 1 Apr 1998

Martín M A, Campos Y, de Bustos F, del Hoyo P, Rubio J C, Arenas J

Abstract excerpt

Mitochondrial biogenesis is the result of the coordinated action of two genomes, nuclear (nDNA) and mitochondrial (mtDNA). Therefore respiratory chain defects are divided into alterations of mtDNA and of nDNA. The former may be due to sporadic isolated deletions and specific duplications and muta...

Topics

DNA, Mitochondrial
Electron Transport
Humans
Phenotype
Point Mutation

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