Coresistance to zidovudine and foscarnet is associated with multiple mutations in the human immunodeficiency virus type 1 reverse transcriptase.

doi:10.1128/AAC.42.11.3038

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Article

Coresistance to zidovudine and foscarnet is associated with multiple mutations in the human immunodeficiency virus type 1 reverse transcriptase.

Antimicrobial agents and chemotherapy - 1 Nov 1998

Tachedjian G, French M, Mills J

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) isolates obtained from a patient with AIDS were assessed for coresistance to foscarnet and zidovudine. An HIV-1 strain (AP20) coresistant to foscarnet and zidovudine was isolated after 20 months of continuous combination therapy. The reverse transcripta...

Topics

Amino Acid Sequence
Anti-HIV Agents
Drug Resistance
Foscarnet
HIV Reverse Transcriptase
HIV-1
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Zidovudine

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