Article
[The hemochromatosis gene (HFE). Molecular analysis--diagnostic applications].
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine - 1 Aug 1998
Ferec C, Raguenes O, Mercier A Y, Le Faou T, Chanu B, Le Poupon A M, Mercier B, Mura C
Abstract excerpt
Hemochromatosis is the most common single gene disorder in Caucasian populations. Regulation of iron balance by intestine is impaired, leading to a widespread deposition of iron, and the disease is associated with an increased risk of hepatocellular carcinoma. Typically the excess of iron treated by phlebotomies is performed in our Blood Center. In 1996 an original paper identifying HFE as a strong candidate gene...
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